NCT01864304

Fat Distribution and Glucose Metabolism in Williams Syndrome

Characterization of Fat Distribution and Glucose Metabolism in Individuals With and Without Williams Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 24 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 14 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Williams Syndrome (WS) is a genetic syndrome with features that may include vascular stenoses, neuro-developmental changes, and a variety of endocrine and metabolic abnormalities, including impaired glucose metabolism and abnormal body composition. Approximately 75% of adults with WS have impaired glucose tolerance or diabetes on oral glucose tolerance testing (OGTT). In addition, clinical observations and preliminary data suggest increased overall body fat in these individuals, as well as a relative increase in fat deposition in the lower extremities. However, glucose and lipid metabolism in WS remain incompletely characterized. The purpose of the current study is to carefully describe glucose metabolism and lipid parameters in people with WS.

Conditions

• Williams Syndrome

Timeline

• Start date: 2013-12-01
• Primary completion: 2016-02-01
• Completion: 2016-02-01
• First posted: 2013-05-29
• Last updated: 2017-01-10

Locations

1 site across 1 country: United States