NCT01863212

The Role of the FTO Gene in Reward System Activation in Obese and Healthy Subjects

Investigating the Role of the FTO Gene in Reward System Activation During Visual Presentation of Food Images With fMRI Technique

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 18 Years – 37 Years
• Healthy volunteers: Accepted

Summary

In order to investigate if individuals, carrying genetic variants predisposing to obesity, respond differently to visual presented food images than non-carriers the investigators aim to screen 500 people for a common risk variant in the FTO gene. From those 500 screened 40 subjects, 20 homozygous for the risk allele and 20 homozygous for a non risk allele will be selected for the second step in the study. This part involves the fMRI technique to visualize the brain response, focus on reward system activation, when food images are visually presented in the scanner. Factors regarding eating behavior, sleep, physical exercise and relation to food are investigated in the first part of the study as well as clinical parameters such as BMI.

Conditions

• Obesity
• Eating Behavior

Interventions

Type	Name	Description
PROCEDURE	Blood sampling for genetic analyse	Blood sampling are performed at the initiation visit in order to screen for allele variants
BEHAVIORAL	Stroop test	Selective attention test where subjects, in one minute, names the ink color of several words without naming the word itself.
OTHER	fMRI	Functional Magnetic Resonance Imaging, performed to view brain activity

Timeline

• Start date: 2010-09-01
• Primary completion: 2014-09-01
• Completion: 2014-09-01
• First posted: 2013-05-27
• Last updated: 2013-05-27

Locations

2 sites across 1 country: Sweden