NCT01862497

Mechanisms of Increased Ambulatory Blood Pressure in Patients With Intradialytic Hypertension

Mechanism of Increased Ambulatory Blood Pressure in Patients With Intradialytic Hypertension and Hemodialysis Controls: A Case Control Study and Crossover Trial Comparing Carvedilol and Prazosin Hydrochloride

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 76 (actual)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is 1) to determine what physiologic factors (extracellular fluid overload or vasoconstriction) contribute more to increased blood pressure levels between dialysis treatments in hemodialysis patients whose blood pressure increases and decreases during hemodialysis and 2) to determine whether carvedilol provides better control of blood pressure between dialysis treatments than prazosin in patients whose blood pressure increases during dialysis.

Conditions

• Intradialytic Hypertension

Interventions

Type	Name	Description
DRUG	Carvedilol vs. Prazosin

Timeline

• Start date: 2013-01-01
• Primary completion: 2018-04-01
• Completion: 2018-04-01
• First posted: 2013-05-24
• Last updated: 2018-05-01

Locations

1 site across 1 country: United States