NCT01860287

The Effects of Buprenorphine on Responses to Verbal Tasks

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: University of Chicago · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In this study, the investigators will examine the effects of buprenorphine, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressful control task in healthy adults. There is strong evidence in support of the role of endogenous opioids and opiates in mediating social behavior in humans and other animals, and particularly, in social distress. Recently it has been shown that buprenorphine, a partial mu-opioid agonist, reduces sensitivity to recognition of fearful facial expressions in humans. Here, the investigators propose to further explore the role of the opioid system in mediating stress responses in humans through the use of buprenorphine. The investigators hypothesize that buprenorphine with reduce both physiological and subjective measures of stress.

Conditions

• Basic Science

Interventions

Type	Name	Description
DRUG	Buprenorphine 0.2 MG Sublingual Tablet	This is a within-subjects, double-blind, placebo-controlled experiment during which each participant will receive sublingual buprenorphine (0.2)
DRUG	Placebo	This is a within-subjects, double-blind, placebo-controlled experiment during which each participant will receive a placebo
DRUG	Buprenorphine 0.4 MG Sublingual Tablet	This is a within-subjects, double-blind, placebo-controlled experiment during which each participant will receive sublingual buprenorphine (0.4)

Timeline

• Start date: 2013-09-01
• Primary completion: 2017-01-01
• Completion: 2017-01-01
• First posted: 2013-05-22
• Last updated: 2019-08-01
• Results posted: 2019-08-01

Locations

1 site across 1 country: United States