NCT01859715

Emergency Department (ED) Drug Interaction in Emergency Department Patients

Hepatic Cytochrome Drug Interactions in Emergency Department Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 502 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 18 Years – 95 Years
• Healthy volunteers: Not accepted

Summary

This study examines how hepatic cytochrome CYP2D6 drug interactions affects the efficacy of oxycodone, hydrocodone, and ondansetron in Emergency Department (ED) patients.

Detailed description

Patients with pain and/or nausea are enrolled in the Emergency Department (ED). They are given either oxycodone, hydrocodone, or ondansetron at the discretion of the Emergency Department (ED) provider or the triage nurse by triage protocol. Detailed prescription, over the counter, herbal, supplement, and illicit drug ingestion histories are taken from the patient or their health care proxy. Serial visual analogue scales are captured prior to study drug administration then between 30 and 90 minutes following drug administration.

Conditions

• Drug Interactions

Interventions

Type	Name	Description
DRUG	Oxycodone	Subjects given oxycodone 5mg by ED provider decision or by triage nurse randomization.
DRUG	Hydrocodone	Subjects given hydrocodone/acetaminophen 5mg/500mg by ED provider decision or by triage nurse randomization.
DRUG	Ondansetron	Subjects given ondansetron 4mg for reported nausea or vomiting. Treatment determined either by triage nursing protocol or by provider discretion. Observational intervention only.

Timeline

• Start date: 2012-06-01
• Primary completion: 2013-01-01
• Completion: 2013-02-01
• First posted: 2013-05-22
• Last updated: 2016-05-05
• Results posted: 2016-05-05

Locations

1 site across 1 country: United States