NCT01858896

GLP-1 and Hypoglycemia

Hypoglycemia Associated Autonomic Dysfunction

• Status: Active Not Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 28 (estimated)
• Sponsor: University of Maryland, Baltimore · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Low blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels. The purpose of this study is to learn if and how glucagon-like peptide-1 (GLP-1; a naturally occurring hormone in the gut) changes the effects that low blood sugar levels have on blood vessels.

Conditions

• Type 2 Diabetes Mellitus

Interventions

Type	Name	Description
DRUG	Glucagon-Like Peptide- 1 (GLP-1) infusion	GLP-1 infusion during experimental period
OTHER	Placebo Comparator: Saline Infusion	Saline infusion (placebo) during experimental period

Timeline

• Start date: 2013-07-01
• Primary completion: 2026-09-01
• Completion: 2026-12-01
• First posted: 2013-05-21
• Last updated: 2025-10-06

Locations

1 site across 1 country: United States