NCT01856959

Lung Function Changes of Induced Asthma Children Treated With Inhaled MgSO4

Response of Asthmatic Children's Lung Function to Nebulized Magnesium Sulfate After Acetylcholine Provocation Test: a Clinical Trail

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 330 (actual)
• Sponsor: Chongqing Medical University · Academic / Other
• Sex: All
• Age: 4 Years – 16 Years
• Healthy volunteers: Accepted

Summary

As a non-selective bronchodilator, magnesium sulfate (MgSO4) is effective when administered intravenously in the treatment of the patients with acute severe asthma not responding to conventional therapy (oxygen, nebulized salbutamol, and corticosteroids), which can resulted in earlier improvement in clinical signs and symptoms of asthma and PEF. However, the use of intravenous MgSO4 administered is not common in clinical practice, because it's prone to have adverse effects and side effects such as nausea, vomiting, facial flushing, hypotension, decreased tendon reflexes and so on with this treatment. The aerosolised route offers the advantage of lower dosage, a shorter time of drug being delivered to the airway smooth muscle and lower incidence of side effects when compared to the intravenous route. At present, there are only a few studies about the effects of nebulized MgSO4 in the treatment of acute asthma in children, and the conclusions are controversial.

Conditions

• Asthma

Interventions

Type	Name	Description
DRUG	Magnesium Sulfate	2ml of 7.5% solution of isotonic magnesium heptahydrate, 150 mg
DRUG	magnesium sulfate & albuterol	0.5ml of albuterol mixed with 2ml of isotonic magnesium sulfate,150mg+2.5mg
DRUG	Albuterol	0.5ml of albuterol mixed with 1.5cc of normal saline, 2.5 mg

Timeline

• Start date: 2011-11-01
• Primary completion: 2013-03-01
• Completion: 2013-05-01
• First posted: 2013-05-20
• Last updated: 2013-05-20

Locations

1 site across 1 country: China