NCT01852539

Dexmedetomidine for Laryngeal Mask Airway Insertion

Optimal Dose of Dexmedetomidine for Laryngeal Mask Airway Insertion During Propofol Induction

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The investigators attempted to determine the optimal dose of dexmedetomidine required for the successful insertion of LMA during propofol induction without a neuromuscular blocking agent.

Detailed description

After a predetermined bolus dose of dexmedetomidine was injected over 2 min, anesthesia was induced with propofol 2.0 mg/kg. After confirming the loss of eyelash reflex and the bispectral index (BIS) score decreased below 60, the insertion of LMA was attempted.

Conditions

• Drug Usage

Interventions

Type	Name	Description
DRUG	dexmedetomidine	The dose of dexmedetomidine was determined by modified Dixon's up-and-down method, starting from 0.5 μg/kg (0.1 μg/kg as a step size).
DRUG	propofol	Propofol 2.0 mg/kg was administrated
DEVICE	laryngeal mask airway (LMA)	The insertion of laryngeal mask airway (LMA) was attempted, after confirming the loss of eyelash reflex,the bispectral index (BIS) score decreased below 60.

Timeline

• Start date: 2013-07-01
• Primary completion: 2013-08-01
• Completion: 2013-08-01
• First posted: 2013-05-13
• Last updated: 2014-04-22

Locations

1 site across 1 country: South Korea