NCT01852461

Perfusion Index Variability in Respiratory Distress Syndrome

Perfusion Index Variability in Preterm Infants Treated With Two Different Natural Surfactants for Respiratory Distress Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 92 (actual)
• Sponsor: Dr. Sami Ulus Children's Hospital · Academic / Other
• Sex: All
• Age: 1 Day – 3 Days
• Healthy volunteers: Accepted

Summary

Perfusion index may vary according to type of surfactant during the treatment of respiratory distress syndrome.

Detailed description

Peripheral tissues of preterm infants are very sensitive for hypoperfusion, but there are rare data in the literature for peripheral perfusion after surfactant treatment. In this study the investigators aimed to compare the perfusion index (PI) variability in premature infants with respiratory distress (RDS) following instillation of one of two different natural surfactant preparations.

Conditions

• Poor Peripheral Perfusion

Interventions

Type	Name	Description
DRUG	Beractant	Beractant;both initial and subsequent dosing is 100 mg/kg (4 mL/kg), which may be given every 6 hours up to four total doses
DRUG	Poractant alfa	porcine lung extract, initial dosing is 200 mg/kg (2.5 mL/kg) and repeated dosing is given at 100 mg/kg (1.25 mL/kg) every 12 hours, up to maximum of two additional doses when indicated

Timeline

• Start date: 2011-08-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2013-05-13
• Last updated: 2013-05-13