NCT01850394

Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement

Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement; A Prospective Triple-blinded Randomized Controlled Trial.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 152 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine 1) the effective dosage of intra-articular tranexamic acid injection for controlling blood loss and blood transfusion requirement in conventional total knee replacement, and 2) whether the blood loss reduction effect depended on the dose of tranexamic acid used.

Conditions

• Primary Osteoarthritis of Knee Nos

Interventions

Type	Name	Description
DRUG	Tranexamic Acid	Inject tranexamic acid solution intra-articularly after fascia closure
DRUG	Physiologic saline	Use physiologic saline for mixing with tranexamic acid or use alone in placebo group

Timeline

• Start date: 2010-01-01
• Primary completion: 2011-01-01
• Completion: 2012-01-01
• First posted: 2013-05-09
• Last updated: 2013-12-13
• Results posted: 2013-12-13

Locations

1 site across 1 country: Thailand