NCT01846364

DIM as a Treatment for Thyroid Disease

Diindolymethane: Anti-proliferation Agent in Thyroid Disease-Non-surgical Protocol

• Status: Terminated
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: The New York Eye & Ear Infirmary · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Diindolylmethane (DIM), a dietary supplement, found naturally in cruciferous vegetables (such as cabbage, cauliflower, broccoli, \& Brussels sprouts) has been studied extensively in recent years for its anti-cancer effects. DIM has been shown to exert control over cancer cell growth in breast, uterine, cervical, ovarian, and colon cancer. To date no human study has been published regarding the bioavailability of DIM in thyroid tissue or its effects in proliferative thyroid disease. Our previous study attempted to elucidate DIM's promotion of anti-proliferative estrogen metabolites in proliferative thyroid disease and ascertain its uptake in thyroid tissue. DIM has been shown to concentrate in the thyroid gland. Furthermore, thyroid volumes have been seen to decrease subjectively. This study would continue our attempt to elucidate DIM's promotion of anti-proliferative estrogen metabolites in proliferative thyroid disease.

Conditions

• Proliferative Thyroid Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Diindolylmethane (DIM)	300 mg of Bioresponse DIM (100mg/day of active DIM) a day for 30 days

Timeline

• Start date: 2006-11-01
• Primary completion: 2011-08-01
• Completion: 2011-09-01
• First posted: 2013-05-03
• Last updated: 2013-05-03

Locations

1 site across 1 country: United States