NCT01843699

Topiramate Trial for Pathological Gamblers

Double-blind Placebo Controlled Topiramate Trial for Pathological Gamblers

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Objectives: Pathological gambling (PG) is a prevalent disorder with no approved pharmacological treatment. Previous reports suggest that topiramate could be useful in reducing impulsivity in PG, and craving in other addictions. The goal of this study was to investigate the effectiveness of topiramate combined with brief cognitive restructuring in treating PG. Methods: 38 PG patients were randomized to either topiramate (N=18) or placebo (N=20) in a 12-week double-blind trial; all patients received brief cognitive restructuring. The main outcome measures were craving, gambling behaviour, gambling cognitive distortions, impulsivity, depression and social adjustment.

Conditions

• Pathological Gambling

Interventions

Type	Name	Description
DRUG	Topiramate flexible dosage
DRUG	Placebo matching tablets
BEHAVIORAL	4-session gambling cognitive restructuring

Timeline

• Start date: 2009-06-01
• Primary completion: 2010-11-01
• First posted: 2013-05-01
• Last updated: 2013-05-03

Locations

1 site across 1 country: Brazil