NCT01840813

Intraumbilical Misoprostol in Retained Placenta

Intra-umbilical Injection of Misoprostol Versus Normal Saline in the Management of Retained Placenta: Intrapartum Placebo-controlled Trial

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: Hawler Medical University · Academic / Other
• Sex: Female
• Age: 15 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Administration of intraumbilical misoprostol to women with retained placenta despite active management of third stage of labour reduces the need for manual removal of placenta and the amount of blood loss vaginally.

Detailed description

Retained placenta (RP)is one of the complications of third stage of labour; it should be managed promptly as it may cause severe bleeding, infection, maternal morbidity and mortality .The current standard management of RP word wide, by manual removal aims to prevent these problems, but it is unsatisfactory method because it requires general anaesthesia in hospital, It is an invasive procedure with its own serious complications of bleeding, infection and genital tract injury. Umbilical vein injection of misoprostol is a simple, safe method and could be performed at the place of delivery .

Conditions

• Retained Placenta

Interventions

Type	Name	Description
DRUG	Misoprostol	It is a synthetic prostaglandin (PgE1 analogue)used as a uterotonic substance.
DRUG	Normal saline	It is a placebo group

Timeline

• Start date: 2011-04-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2013-04-26
• Last updated: 2013-11-05

Locations

1 site across 1 country: Iraq