NCT01840020

BAR-trial: Bioavailability of Ethanol Following Bariatric Surgery

Changes in Bioavailability of Ethanol Following Bariatric Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 33 (actual)
• Sponsor: Norwegian University of Science and Technology · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The first-pass metabolism (FPM) is a barrier to the toxicity of ethanol. Changes to the size and function of the stomach may alter FPM. Bariatric surgery, like the gastric bypass procedure, involves significant changes to the size and function of the stomach and leads to more rapid gastric emptying. Consequences will be faster absorption and higher peak concentration of ethanol after surgery than before. There are growing concerns that surgery for obesity in this way may cause alcohol abuse. In this study the investigators compare changes in FPM of ethanol following two different bariatric surgical procedures.

Conditions

• Obesity, Morbid

Interventions

Type	Name	Description
PROCEDURE	Gastric bypass	Surgical procedure in which the stomach is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the small intestine by an end-to-side surgical anastomosis.
PROCEDURE	gastric sleeve	Sleeve gastrectomy, a surgical procedure in which the stomach is reduced to about 25% of its original size, by surgical removal of a large portion of the stomach, following the major curve. The open edges are then attached together (often with surgical staples) to form a sleeve or tube with a banana shape.

Timeline

• Start date: 2013-09-01
• Primary completion: 2020-02-01
• Completion: 2020-02-01
• First posted: 2013-04-25
• Last updated: 2020-02-26

Locations

2 sites across 1 country: Norway