NCT01835353

High (100mg) Versus Standard (60mg) Loading Dose of Prasugrel in Patients With ST-elevation Myocardial Infarction (STEMI), Undergoing Primary Percutaneous Coronary Intervention (PCI)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: University of Patras · Academic / Other
• Sex: All
• Age: 18 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, multi-center, non-randomized, controlled study in 2 sequential groups of P2Y12 inhibitor-naive consecutive STEMI patients undergoing primary PCI. Following aspirin 325 mg LD, patients will receive 60 mg or 100 mg of prasugrel, respectively. Platelet reactivity (PR)will be assessed at Hour 0 (before prasugrel's administration immediately prior to PCI) and at Hours 0.5, 1, 2, 4 thereafter. Platelet function testing (in PRU) will be performed with the VerifyNow (Accumetrics Inc., San Diego, CA, USA) P2Y12 function assay.

Conditions

• Platelet Reactivity

Interventions

Type	Name	Description
DRUG	Prasugrel 100mg loading dose
DRUG	Prasugrel 60mg loading dose	Prasugrel 60mg loading dose

Timeline

• Start date: 2012-06-01
• Primary completion: 2013-07-01
• Completion: 2013-07-01
• First posted: 2013-04-18
• Last updated: 2013-09-23

Locations

1 site across 1 country: Greece