NCT01834092

Study of the Glycocalyx in Abdominal Aortic Aneurysm

Measurement of the Endothelial Function in Patients With a Abdominal Aortic Aneurism.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators want to measure the degradation of the endothelial glycocalyx before and after clamping the aorta, in patients operated for a abdominal aortic aneurism.

Detailed description

50 patients is scheduled for enrollment. Blood samples will be up taken before surgery, 10 min after reperfusion, at the end of surgery and the following morning. In addition the investigators are placing a renal venous catheter where blood samples will be up taken as mentioned above for the analysis of endothelial markers together with markers for kidney damage. The first 10 patient will act as part of a pilot study, where only measurement of the endothelial and renal failure markers will be performed.

Conditions

• Abdominal Aortic Aneurism
• Surgery
• Ischemic Reperfusion Injury

Interventions

Type	Name	Description
OTHER	Plasma	2 Units of plasma transfused equvilant to 2 times 275ml

Timeline

• Start date: 2013-04-01
• Primary completion: 2014-06-01
• Completion: 2014-07-01
• First posted: 2013-04-17
• Last updated: 2013-04-17

Locations

1 site across 1 country: Denmark