NCT01833455

Premature Ventricular Contractions (PVCs) and Blood Pressure Control

The Effects of PVC Suppression on Blood Pressure Control in Patients With Frequent PVCs

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if reduction in premature ventricular contraction (PVC) burden results in a decrease in blood pressure, sympathetic outflow, plasma catecholamines and an improvement in baroreflex gain. Flecainide will be used for PVC suppression in a randomized, double-blinded, crossover fashion.

Conditions

• Ventricular Premature Complexes
• Blood Pressure

Interventions

Type	Name	Description
DRUG	PVC Suppression using Flecainide	Flecainide will be administered to result in a reduction in PVC burden.
DRUG	No PVC Suppression using Placebo	Placebo (sugar pills) will be given to result in no alteration in PVC burden.

Timeline

• Start date: 2013-02-01
• Primary completion: 2016-06-01
• Completion: 2016-06-01
• First posted: 2013-04-16
• Last updated: 2019-02-22
• Results posted: 2019-02-22

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study