NCT01832662

Coffee Polyphenols Antioxidants

Coffee Antioxidant Efficacy in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Société des Produits Nestlé (SPN) · Industry
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Coffee is one of the most widely consumed beverages. It contains polyphenols (chlorogenic acids) and bioavailability of these bioactive compounds is now somewhat well understood. In addition, chlorogenic acids are known to be antioxidants in the cup, but reliable evidence remains to be observed in vivo. The objective of this trial is to understand if regular (10d) coffee intake may be beneficial on biomarkers of oxidative damage measured in urine and plasma. A secondary objective is to understand if polyphenols isolated from coffee may be as beneficial as the whole beverage in reducing oxidative stress compared to placebo

Detailed description

This is an interventional study with a crossover randomized placebo-controlled double-blind design to assess the effect of regular consumption of coffee on oxidative stress compared to placebo.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	coffee	coffee, placebo enriched with polyphenols and placebo with caffeine
OTHER	coffee polyphenols mixed with placebo	coffee polyphenols mixed with placebo
OTHER	maltodextrin enriched with caffeine	maltodextrin enriched with caffeine

Timeline

• Start date: 2011-03-01
• Primary completion: 2012-04-01
• Completion: 2013-06-01
• First posted: 2013-04-16
• Last updated: 2014-04-21