NCT01832129

Vitamin B12 Acceptance and Biomarker Response Study

Acceptance and Biomarker Response With Oral vs. Intramuscular Supplementation of Vitamin B12 in Primary Care

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this study, biomarker response after supplementation with oral and intramuscular vitamin B12 will be compared in a randomized clinical trial. Electronic compliance monitoring will be used to control for non compliance as a possible confounder in oral treatment. Additionally subjective acceptance in terms of presumed preferences will be compared with oral vs. intramuscular supplementation of vitamin B12 in the view of the patient.

Conditions

• Vitamin B 12 Deficiency

Interventions

Type	Name	Description
DRUG	Oral administration of vitamin B12	Daily high dose oral vitamin B12 (1mg) will be administered over 4 weeks. The patients adherence to this regimen will be monitored with an electronic punch card.
DRUG	i.m. injection of vitamin B12	Intramuscular injections of 1 mg vitamin B12 will be performed at days 7, 14, and 21.

Timeline

• Start date: 2013-05-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2013-04-15
• Last updated: 2016-06-14

Locations

1 site across 1 country: Switzerland