NCT01824758

Effect of Esmolol on Pain Due to Rocuronium

The Effect of Esmolol on Pain Due to Rocuronium Injection Pain

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Ankara Diskapi Training and Research Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

90 American society of anesthesiology (ASA) physical status I and II patients undergoing general anesthesia for elective surgery will be included in the study. Patients will be randomized into three groups. Group E will receive esmolol (1 mg/kg), Group IL lidocaine (0.5 mg/kg)and Group C placebo(NaCl 0.9%, 5 mL), followed by a 0.05 mg/kg rocuronium. After intravenous induction with propofol, adequate muscle relaxation for intubation will be received by 0.5 mg/kg rocuronium.

Detailed description

Patients will be observed after injection of rocuronium 0.05mg/kg, then immediately asked if they have pain in the arm. The response are assessed; discomfort, pain, and withdrawal of the hand are recorded and graded using a 4-point scale (none, mild, moderate, or severe). After the intubating dose of rocuronium, withdrawal reactions are scored as follows: (a) no pain response, (b)pain limited to the wrist, (c) pain limited to the elbow/shoulder, or (d) generalized pain response.

Conditions

• Injection Site Irritation

Interventions

Type	Name	Description
DRUG	Lidocaine	Group L lidocaine (0.5 mg/kg), (rocuronium) (0.05mg/kg).
DRUG	Esmolol	Group E: esmolol (1 mg/kg), (rocuronium) (0.05mg/kg)
DRUG	rocuronium	0.05 mg/kg rocuronium
DRUG	Placebo	Group C: Placebo (NaCl 0.9%, 5 ml), (rocuronium) (0.05mg/kg)

Timeline

• Start date: 2013-03-01
• Primary completion: 2013-04-01
• Completion: 2013-05-01
• First posted: 2013-04-05
• Last updated: 2019-10-04

Locations

1 site across 1 country: Turkey (Türkiye)