NCT01823744

Harmonized Micronutrient Project

A New Strategy to Analyze Gene-Nutrient Interaction in Children and Adolescents

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 146 (actual)
• Sponsor: Société des Produits Nestlé (SPN) · Industry
• Sex: All
• Age: 9 Years – 13 Years
• Healthy volunteers: Accepted

Summary

The purpose of this trial is to better define how individuals with different genetic make-ups will require different interventions to improve their methylation potential and nutrient status.

Detailed description

Despite the increasing incidence of overweight and obesity among children, nutritional deficiencies are still a concern. A low intake of vitamins and minerals is associated with a reduction in the antioxidant capacity. Some vitamins are associated with chronic diseases including overweight and obesity. S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are the substrate and product of essential reactions; the SAM:SAH ratio has been associated with health and is an indicator of cellular DNA methylation potential. Low level of this ratio may affect short and long term health. In this explorative knowledge building open interventional study, subject to be enrolled are children or adolescents 9 to 13 years of age per year (n=180 per year, over 2 years). The study consists of 6 weeks nutritional intervention followed by a 6 weeks follow up. In this study, genomics, proteomics, lipidomics analysis will be performed, in addition to biochemistry, hematology and vitamins analysis.

Conditions

• Genomic

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	micronutrient supplementation

Timeline

• Start date: 2013-03-01
• Primary completion: 2014-06-01
• Completion: 2014-06-01
• First posted: 2013-04-04
• Last updated: 2014-08-05

Locations

1 site across 1 country: Brazil