NCT01823263

Metabolic and Cognitive Parameters Following Partial Sleep Deprivation

Metabolic and Cognitive Effects of Sleep Deprivation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Uppsala University · Academic / Other
• Sex: Male
• Age: 20 Years – 28 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether partial sleep deprivation, as compared with normal sleep, influences certain metabolic and cognitive parameters, related to food intake, hunger and memory functions, when participants are shielded from external time cues.

Detailed description

It is predicted that partial sleep deprivation negatively affects the hormonal status, e.g. upregulating ghrelin and other hunger-promoting hunger hormones, while showing impaired memory functions. It is also predicted that participants will tend to increase their desired portion sizes after partial sleep deprivation, compared with after a normal night's sleep.

Conditions

• Sleep Deprivation
• Sleep

Interventions

Type	Name	Description
BEHAVIORAL	Portion Size Task	Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume
PROCEDURE	Blood sample	In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
PROCEDURE	Interference task	30-minute interference task
BEHAVIORAL	Memory tasks	Participants will be allowed to learn a procedural memory task before going to bed. Participants will be retested in the morning to assess their change in performance. Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
BEHAVIORAL	Intake task	After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window. Amount and selection will be recorded
BEHAVIORAL	Working memory function task	Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)

Timeline

• Start date: 2013-04-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2013-04-04
• Last updated: 2014-12-02

Locations

1 site across 1 country: Sweden