NCT01822860

Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function

The Effect of Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function in Hypertensive Patients: A Pilot Study

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Creighton University · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

Chlorthalidone will result in improved endothelial function compared to hydrochlorothiazide as measured by flow mediated vasodilatation.

Detailed description

This is a randomized, double-blind, crossover study to evaluate chlorthalidone and hydrochlorothiazide and their effects on endothelial function in hypertensive patients. Subjects will receive chlorthalidone 12.5 mg, hydrochlorothiazide 25 mg, and placebo each for 4 weeks with a 1 week washout between study periods. Sequence of study drugs will be randomized. Flow mediated vasodilatation will be measured at baseline and after each treatment period.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Chlorthalidone 12.5 mg
DRUG	Hydrochlorothiazide 25 mg
DRUG	Placebo

Timeline

• Start date: 2013-03-01
• Primary completion: 2015-02-01
• Completion: 2015-02-01
• First posted: 2013-04-02
• Last updated: 2015-03-25

Locations

1 site across 1 country: United States