NCT01817803

A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1)

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients

Conditions

• Congestive Heart Failure

Interventions

Type	Name	Description
DRUG	furosemide/no spironolactone	furosemide (doubling previous furosemide dose)
DRUG	metolazone/no spironolactone	metolazone (add 2.5mg qod)
DRUG	furosemid/spironolactone	furosemide (doubling previous furosemide dose)+spironolactone (doubling previous spironolactone dose or add 12.5mg BID if previous non-user)
DRUG	metolazone/spironolactone	metolazone (add 2.5mg qod)+ spironolactone (doubling previous spironolactone dose or add 12.5mg BID if previous non-user)

Timeline

• Start date: 2013-03-01
• Primary completion: 2015-06-01
• Completion: 2015-12-01
• First posted: 2013-03-25
• Last updated: 2014-02-19