NCT01812941

Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of South Alabama · Academic / Other
• Sex: All
• Age: 19 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The purpose of this project is to evaluate the level of mitochondrial dysfunction several patient populations: Burn, trauma, and control group of healthy volunteers. Study hypothesis: Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients. As the severity of a burn injury or trauma injury increase, so will systemic mitochondrial dysfunction.

Detailed description

Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients. A normal healthy sub-population will be used as a control.

Conditions

• Burns
• Trauma

Interventions

Type	Name	Description
OTHER	trauma: blood collection	Blood samples collected at certain timepoints. Time points for burn/trauma subjects: Day0,Day1,Day2,and Day6 and Day7.
OTHER	healthy volunteers: blood collection	blood collected at designated time intervals
OTHER	Burn: blood collection	blood collected at designated time intervals

Timeline

• Start date: 2011-09-01
• Primary completion: 2021-12-01
• Completion: 2021-12-01
• First posted: 2013-03-18
• Last updated: 2021-05-28

Locations

1 site across 1 country: United States