NCT01809054

Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 54 (actual)
• Sponsor: LifeBridge Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, randomized study from pre-surgery to 6 weeks post-surgery designed to detect changes in coagulability following elective total knee and hip arthroplasty. Patients will be randomized to one of the two standard prophylaxis treatments used at Sinai Hospital: 1. Arixtra (2.5 mg SQ/QD) subcutaneous injection daily for 2 weeks followed by aspirin 325 mg for 5 weeks, or 2. Pneumatic compression stockings (MCS, Active Care, medical compression systems Inc., Israel) for 2 weeks with concomitant Aspirin 325 mg daily for 5 weeks.

Conditions

• Primary Total Hip and Knee Arthroplasty

Interventions

Type	Name	Description
DRUG	Arixtra
DEVICE	Pneumatic compression stockings	Pneumatic compression stockings (MCS, Active Care, medical compression systems Inc., Israel)
DRUG	Aspirin

Timeline

• Start date: 2012-04-01
• Primary completion: 2013-02-01
• Completion: 2013-02-01
• First posted: 2013-03-12
• Last updated: 2014-04-21
• Results posted: 2014-04-21

Locations

2 sites across 1 country: United States