NCT01805934

Quadruple Therapy Versus Dual Therapy as Rescue Regimens for Helicobacter Pylori Infection

Quadruple Therapy With Furazolidone Versus Dual Therapy With High Doses of Amoxicillin as Rescue Regimens for Helicobacter Pylori Infection

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 114 (actual)
• Sponsor: Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The eradication rates of first-line treatment for Helicobacter pylori(Hp) infection are not satisfactory. The study aims to compare the efficacy and safety between quadruple therapy with furazolidone and dual therapy with high doses of amoxicillin as rescue regimens for Hp.

Conditions

• Rescue Therapy for Helicobacter Pylori

Interventions

Type	Name	Description
DRUG	RBLF	The patients in Group RBLF will receive a 14-day quadruple therapy,including rabeprazole(10mg bid),bismuth citrate(220mg bid),levofloxacin(200mg qm) and furazolidone(100mg bid).
DRUG	RA	The patients in Group RA will be sent to a penicillin skin test before treatment except they were given penicillin before. They will receive a 14-day dual therapy with high doses of rabeprazole(20mg bid) and amoxicillin(1000mg tid).

Timeline

• Start date: 2012-05-01
• Primary completion: 2012-12-01
• Completion: 2013-02-01
• First posted: 2013-03-06
• Last updated: 2013-03-06

Locations

1 site across 1 country: China