NCT01799109

Lung Function of Asthmatic Children by Nebulized MgSO4

Lung Function Changes of Mild to Moderate Asthmatic Children Treated by Nebulized MgSO4

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Chongqing Medical University · Academic / Other
• Sex: All
• Age: 4 Years – 10 Years
• Healthy volunteers: Accepted

Summary

Asthma is a common chronic respiratory illness which results in frequent wheezing, cough,reduced quality of life. Standard treatment for asthma attack includes oxygen therapy, β2-agonists (e.g. albuterol) and inhaled anticholinergics and corticosteroids. Although inhaled short-acting β2-agonists (SAB) is the initial choice to control acute asthma exacerbation, there are still some asthmatic children unresponsive to this management. The Global Initiative in National Asthma (GINA) does not recommend intravenous magnesium sulfate (MgSO4) for routine use in asthma exacerbation especially in young children. But intravenous MgSO4 can reduce hospital admission rates in certain patients due to several effects e.g relaxation of smooth muscle,blocking acetylcholine. In addition,adding MgSO4 to nebulized SAB provides greater benefit in severe asthma exacerbation.

Conditions

• Asthma

Interventions

Type	Name	Description
DRUG	Magnesium Sulfate & albuterol
DRUG	albuterol
DRUG	magnesium

Timeline

• Start date: 2011-11-01
• Primary completion: 2012-01-01
• Completion: 2012-03-01
• First posted: 2013-02-26
• Last updated: 2013-05-21

Locations

1 site across 1 country: China