NCT01798836

Oestradiol Pre-treatment in an Ultrashort Flare GnRH Agonist/GnRH Antagonist Protocol in Poor Responders Undergoing IVF

• Status: Terminated
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: National and Kapodistrian University of Athens · Academic / Other
• Sex: Female
• Age: 25 Years – 44 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the effect of oestradiol pre-treatment in a combined ultrashort flare GnRH agonist /GnRH antagonist protocol

Detailed description

The combined ultrashort flare GnRH agonist /GnRH antagonist protocol during COH cycle resulted in a significantly higher clinical pregnancy rate in patients with poor embryo quality, with repeated IVF failures and in poor responders. This is a protocol combining the effect of the microdose flare on endogenous FSH release with the benefit of an immediate LH suppression of the GnRH antagonist. A major disadvantage of the use of a GnRH antagonist protocol is the limitation for programming cycles, as the drugs administration is started on day 2 of the menstrual cycle and is strictly followed until the hCG criteria are met. The purpose of the study is to perform oestradiol pre-treatment with the combined ultrashort flare GnRH agonist /GnRH antagonist protocol aiming to 1. better programme an antagonist cycle and 2. improve the IVF outcome parameters, from the production of more follicles / oocytes up to the rise in live birth rates.

Conditions

• Infertility

Interventions

Type	Name	Description
PROCEDURE	Oestradiol pre-treatment and combination of GnRH agonist/antagonist protocol
PROCEDURE	GnRH agonist or antagonist protocol without oestradiol pre-treatment

Timeline

• Start date: 2013-02-01
• Primary completion: 2015-01-01
• Completion: 2015-02-01
• First posted: 2013-02-26
• Last updated: 2015-08-06

Locations

1 site across 1 country: Greece