NCT01798173

Environmental, Metabolic and Nutritional Factors of Hepatocellular Carcinoma in Cirrhotic Patients

CIRCE: Environmental, Metabolic and Nutritional Factors of Hepatocellular Carcinoma in Cirrhotic Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,246 (actual)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: All
• Age: 35 Years
• Healthy volunteers: Not accepted

Summary

Available data do not allow carcinogenesis mechanisms in cirrhotic patients to be well understood in absence of studies taking into account all recognised factors. A large scale clinical, biochemical and molecular studies is potentially relevant to the understanding of nutrition, physical activity, body weight metabolic syndrome whatever the etiology of underlying cirrhosis. It will open new perspectives : * in prevention of hepatocellular carcinoma development in cirrhotic patients through dietary counselling and therapeutics of metabolic syndrome, * in early screening of hepatocellular carcinoma in cirrhotic patients through spectroscopic technology and later proteomic study resulting in an improvement of hepatocellular carcinoma prognosis.

Conditions

• Cirrhosis With Hepatocellular Carcinoma
• Cirrhosis Without Hepatocellular Carcinoma

Interventions

Type	Name	Description
BIOLOGICAL	Serum, plasma and DNA samples
PROCEDURE	Radiological exploration by CT scan or MRI

Timeline

• Start date: 2008-06-20
• Primary completion: 2018-01-25
• Completion: 2018-01-25
• First posted: 2013-02-25
• Last updated: 2022-04-21

Locations

6 sites across 1 country: France