NCT01795144

Incretin Regulation of Insulin Secretion in Monogenic Diabetes

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University of Chicago · Academic / Other
• Sex: All
• Age: 18 Years – 89 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to explore the mechanisms of metabolic control in monogenic diabetes patients treated with sulfonylurea medications.

Detailed description

Monogenic diabetes patients and healthy matched controls will be admitted to the University of Chicago Clinical Resource Center for a total of 4 nights. The following will take place on separate days: 1. Oral Glucose Tolerance Test (OGTT): consume sugary drink and blood samples will be collected at multiple time points 2. Isoglycemic glucose infusion (IGI) test: glucose will be infused via a vein in the arm and and blood samples will be collected at multiple time points 3. OGTT during GLP-1 infusion 4. IGI during Exendin-9 infusion

Conditions

• Monogenic Diabetes

Interventions

Type	Name	Description
DRUG	GLP-1	OGTT IGI IGI with GLP-1 infusion OGTT with Exendin 9-39 infusion
DRUG	Exendin 9-39	OGTT IGI IGI with GLP-1 infusion OGTT with Exendin 9-39 infusion

Timeline

• Start date: 2014-01-01
• Primary completion: 2017-03-01
• Completion: 2017-03-01
• First posted: 2013-02-20
• Last updated: 2017-04-10

Locations

1 site across 1 country: United States