NCT01783340

Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis

• Status: Withdrawn
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study will assess the superior protective immunity of the combination of chloroquine and azithromycin prophylaxis under Chemoprophylaxis Sporozoites (CPS) immunization versus a standard chloroquine prophylactic regimen.

Detailed description

This study assesses the superiority of protective immunity of the combination of chloroquine and azithromycin prophylaxis under Chemoprophylaxis Sporozoites (CPS) immunization versus a standard chloroquine prophylactic regimen.

Conditions

• Malaria, Falciparum

Interventions

Type	Name	Description
DRUG	Azithromycin capsules	Azithromycin capsules will be administered at each immunization
DRUG	Placebo	Placebo capsules will be administered at each immunization
BIOLOGICAL	Immunization with falciparum	three inoculations with 5 infected mosquito bites

Timeline

• Start date: 2013-04-01
• Primary completion: 2013-12-01
• Completion: 2014-04-01
• First posted: 2013-02-04
• Last updated: 2014-11-13

Locations

1 site across 1 country: Netherlands