NCT01781923

Cognitive Remediation in 22q11DS

A Remediation Program for Children at High-Risk of Schizophrenia: 22q11.2 Deletion Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 11 Years – 17 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to collect preliminary data on the efficacy of a cognitive remediation program in improving the neurocognitive deficits in children with chromosome 22q11.2 deletion syndrome (22q11DS). This study involves a two part approaching including a computerized cognitive remediation program (CCRP, Posit Science, CA) in combination with a Social Cognitive Training (SCT) program. The computer-based training program has shown encouraging results in improving learning deficits in individuals with schizophrenia and we now seek to adapt them to children with 22q11DS, who have unique needs due to their lower IQ and high risk of psychosis in late adolescence and adulthood. The SCT is a small-group intervention program based on cognitive enhancement therapy, which has been shown to improve social cognition and functionality in adults with schizophrenia. A preliminary study will be performed using this two-pronged approach, to establish the feasibility and gather preliminary data on neurocognition before and after the intervention in these children; these data would enable a larger randomized controlled study to assess the efficacy of this approach.

Conditions

• 22q11.2 Deletion Syndrome
• Velo-Cardio-Facial Syndrome

Interventions

Type	Name	Description
BEHAVIORAL	Cognitive remediation program	Subject plays for 30 minutes, 4 times per week, for 12 weeks.
BEHAVIORAL	Small group social skills training	Meet once per week for duration of 40 weeks.

Timeline

• Start date: 2010-10-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2013-02-01
• Last updated: 2015-08-10

Locations

1 site across 1 country: United States