NCT01780922

Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress

Acute Bioavailability of Cranberry Polyphenols After A Single Dose In Healthy Adults and Its Antioxidative and Anti-Inflammatory Action

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Washington State University · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the effects of a single dose of cranberry beverage in healthy adults on the kinetic uptake of polyphenol compounds and polyphenol metabolites, and antioxidative and anti-inflammatory activity.

Detailed description

Participants will be randomized based on age, sex and BMI, and will consume a low-polyphenol diet 2 days prior to the intervention. On the day of the study, baseline blood and urine samples will be collected after an overnight fast. Participants will consume the assigned beverage within 15 minutes and blood collected at 2, 4, 8, and 24 h (10 mL/blood draw; total blood volume per period = 50 mL). Urine will be collected for polyphenol analysis during the following periods: 0-3, 3-6, 6-9, 9-12, 12-24 hours. After a one-week washout period, participants will receive their second and then the third beverage in a cross-over design; blood and urine sampling will be repeated at each of the 3 intervention periods.

Conditions

• Inflammation

Interventions

Type	Name	Description
OTHER	Low Calorie Cranberry Juice Cocktail	Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
OTHER	Cranberry Extract Beverage	Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
OTHER	Non-Cranberry Beverage	Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes

Timeline

• Start date: 2010-07-01
• Primary completion: 2010-10-01
• Completion: 2010-12-01
• First posted: 2013-01-31
• Last updated: 2014-07-08
• Results posted: 2014-07-08

Locations

1 site across 1 country: United States