NCT01778309

NAC Supplementation and Skeletal Muscle Performance

Effects of NAC Supplementation on Skeletal Muscle Performance Following Aseptic Injury Induced by Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Democritus University of Thrace · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

In this investigation the investigators utilized NAC administration to foster GSH availability during an 8-day period following eccentric exercise-induced muscle damage in order to test our hypotheses: i) antioxidant supplementation does not disturb performance and adaptations induced by exercise-induced muscle injury and ii) redox status perturbations in skeletal muscle are pivotal for the regulation of muscle' inflammatory response and repair.

Detailed description

The major thiol-disulfide couple of reduced (GSH) and oxidized glutathione (GSSG) is a key-regulator of major transcriptional pathways regulating aseptic inflammation and recovery of skeletal muscle following aseptic injury. Antioxidant supplementation may hamper exercise-induced cellular adaptations. Our objective was to examine how thiol-based antioxidant supplementation affects skeletal muscle's performance and redox-sensitive signalling during the inflammatory and repair phases associated with exercise-induced micro-trauma.In a double-blind, counterbalanced design, 12 men received placebo (PLA) or N-acetylcysteine (NAC, 20 mg/kg/day) following muscle-damaging exercise (300 eccentric contractions). In each trial, muscle performance was measured at baseline, post-exercise, 2h post-exercise and daily for 8 consecutive days. Muscle biopsies from vastus lateralis and blood samples were collected pre-exercise and 2h, 2d, and 8d post-exercise.

Conditions

• Skeletal Muscle Damage
• Skeletal Muscle Performance
• Intgracellular Signaling in Skeletal Muscle
• Inflammatory Status

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	n-acetylcysteine supplementation	n-acetylcysteine administration: 20 mg//kg/day, orally, daily for eight days following exercise placebo administration: 500 mL orally, daily for eight days following exercise

Timeline

• Start date: 2010-01-01
• Primary completion: 2011-09-01
• Completion: 2012-04-01
• First posted: 2013-01-29
• Last updated: 2013-01-29

Locations

1 site across 1 country: Greece