NCT01777464

Role of the Central Nervous System in Allergic Rhinitis

Role of the Central Nervous System in Allergic Rhinitis: Activation of Different Brain Regions After a Nasal Histamine Provocation in Healthy and Allergic Patients

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Universitaire Ziekenhuizen KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

In order to evaluate the effects a nasal provocation on the activation of different brain regions, the investigators want to set up a clinical trial investigating the short-term effects of a nasal histamine provocation in healthy volunteers and allergic patients while in supine position under the functional MRI device in order to visualize different brain regions.

Detailed description

Evaluate the effects a nasal provocation on the activation of different brain regions

Conditions

• House Dust Mite Allergy

Interventions

Type	Name	Description
BIOLOGICAL	histamine	administration of histamine solution (16 mg/ml) via aerosol for 5 minutes while lying under a fMRI scan
BIOLOGICAL	sham	sham solution

Timeline

• Start date: 2012-11-01
• Primary completion: 2016-02-01
• Completion: 2016-03-01
• First posted: 2013-01-28
• Last updated: 2015-12-03

Locations

1 site across 1 country: Belgium