NCT01777451

Whole Body Magnetic Resonance Imaging With Diffusion Weighted Imaging : Potential Role in Neurofibromatosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Universitaire Ziekenhuizen KU Leuven · Academic / Other
• Sex: All
• Age: 6 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Whole body MRI will be performed in patients with neurofibromatosis Type 1 PURPOSE 1: To determine the total tumor load (neurofibroma) and to diagnose plexiform neurofibromas or malignant peripheral nerve sheath tumors. All patients will be scanned two years after the baseline whole body MRI to investigate to investigate the changes of total tumor load. PURPOSE 2: added value of diffusion weighted imaging in diagnosis of high-risk neurofibromas PURPOSE 3 : to determine the apparent diffusion coefficient of the malignant nerve sheath tumors and neurofibroma. PURPOSE 4 : correlation between histopathology of the surgically resected neurofibroma/malignant nerve sheath tumors and MRI findings

Conditions

• Whole Body Imaging
• Magnetic Resonance Imaging
• Neurofibromatosis 1
• Diffusion Magnetic Resonance Imaging
• Peripheral Nerve Sheath Tumors, Malignant

Interventions

Type	Name	Description
OTHER	Additional imaging or surgery	No specific intervention is necessary. If a suspicious lesion is diagnosed on MRI, further investigation will be planned (PET-CT or surgery - biopsy)

Timeline

• Start date: 2010-12-01
• Primary completion: 2013-01-01
• Completion: 2014-01-01
• First posted: 2013-01-28
• Last updated: 2013-01-28

Locations

1 site across 1 country: Belgium