NCT01775748

Effect of Concord Grape Juice on Endothelial Function

Effect Of Concord Grape Juice On Endothelial Function In Obese And Overweight Individuals Over Age 50

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 77 (actual)
• Sponsor: Boston University · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

The study will compare Concord grape juice to a beverage that contains no grape flavonoids, but has a similar appearance and taste (placebo juice). A total of 60 overweight and obese participants over age 50 will be enrolled. Each participant will drink each beverage for 4 weeks with a 2-week rest period between two beverage consumption periods. The order of beverages (grape juice first or placebo juice first) will be randomized. The investigators will use ultrasound to measure brachial artery flow-mediated dilation, a measure of endothelial vasodilator function. The investigators will also collect blood samples to further assess the cardiovascular effects of grape juice. The aim of the study is to determine whether Concord grape juice improves endothelial function in patients at risk who do not have cardiovascular disease and may provide information that would guide dietary recommendations. The results may also be used by the sponsor to substantiate claims and labeling of their product.

Conditions

• Obesity
• Overweight

Interventions

Type	Name	Description
OTHER	Active Concord Grape Juice 12 oz per day	Grape Juice 12 oz per day
OTHER	Placebo Grape Juice 12 oz per day	Placebo Grape Juice 12 oz per day

Timeline

• Start date: 2013-01-01
• Primary completion: 2014-03-19
• Completion: 2014-03-19
• First posted: 2013-01-25
• Last updated: 2018-02-12

Locations

1 site across 1 country: United States