NCT01774305

Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 141 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Coughing during emergence from general anaesthesia may lead to dangerous effects including laryngospasm, detrimental haemodynamic changes. Post-thyroidectomy bleeding occurs in 1-4% of patients, and severe coughing may cause bleeding. Dexmedetomidine, a potent α adrenoreceptor agonist, is theoretically appropriate for reducing airway and haemodynamic reflexes during emergence from anaesthesia. In this study, we investigated whether intravenous single-dose dexmedetomidine at the end of surgery reduces coughing during extubation after thyroidectomy.

Conditions

• Coughing

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	We administrate the dexmedetomidine single bolus (0.5ug/kg, intravenously) at time of muscle layer closing.
DRUG	Saline	We administrate the normal saline (single bolus, 0.25ml/kg) intravenously at time of muscle layer closing.

Timeline

• Start date: 2012-12-01
• Primary completion: 2013-01-01
• Completion: 2013-06-01
• First posted: 2013-01-23
• Last updated: 2014-02-10
• Results posted: 2013-08-22

Locations

1 site across 1 country: South Korea