NCT01774292

Effect of Intracuff Alkalinized Lidocaine on Coughing Incidence at Extubation

Evaluation of the Effect of Intracuff Alkalinized Lidocaine on Coughing Incidence at Extubation in Surgeries Without Nitrous Oxide Lasting More Than 2 Hours

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determined whether the administration of alkalized 4% lidocaine (160 mg) in the endotracheal tube cuff is effective in diminishing the incidence of coughing at extubation in surgeries lasting more than 2 hours without the use of nitrous oxide as an anesthetic agent.

Detailed description

The diffusion of nitrous oxide inside the endotracheal cuff leads to increase pressure, pain and coughing. Studies have shown benefit of alkalized lidocaine and other mediums within the cuff with nitrous oxide. No study has yet evaluated the benefit of alkalized lidocaine in long surgeries without the use of nitrous oxide.

Conditions

• Coughing
• Extubation
• Lidocaine
• Endotracheal Cuff

Interventions

Type	Name	Description
PROCEDURE	Endotracheal intubation with injection of liquid in the cuff

Timeline

• Start date: 2013-01-01
• Primary completion: 2014-06-01
• Completion: 2014-11-01
• First posted: 2013-01-23
• Last updated: 2015-10-30

Locations

1 site across 1 country: Canada