NCT01767298

Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide (Double Doses)

Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide: An Open-Label, Randomized, Four-Period Crossover Study in Healthy Egyptian Male Volunteers (PART II)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Damanhour University · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study was conducted to compare the rate and extent of absorption of valsartan and hydrochlorothiazide. To maximize the possibility of finding drug-drug interactions, the dose of valsartan and hydrochlorothiazide was doubled (320 mg of VAL and 25 mg of HCT).

Conditions

• Healthy Normotensive Participants

Interventions

Type	Name	Description
DRUG	Valsartan/Hydrochlorothiazide	Co-administration or fixed dose combination
DRUG	Valsartan	Valsartan alone
DRUG	Hydrochlorothiazide	Hydrochlorothiazide alone

Timeline

• Start date: 2012-10-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2013-01-14
• Last updated: 2013-01-14