NCT01760278

Assessment of Implantation Potential of Embryos by Time-lapse Technology

Assessment of Implantation Potential of Embryos Cultured by Time-lapse Technology (Embryoscope) Before Transfer in In-vitro Fertilization (IVF) / Intracytoplasmic Sperm Injection (ICSI) Cycles: A Randomized Control Study.

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Bloom IVF and Fertility Centre · Academic / Other
• Sex: Female
• Age: 21 Years – 39 Years
• Healthy volunteers: Accepted

Summary

1. Culture conditions of developing embryos are highly controlled in the Embryoscope and are monitored by Time-lapse videography to produce 3D images at different stages.This cannot be done under conventional culture conditions. 2. The 3D images thus produced,are analysed with the help of Embryoviewer, a part of the Embryoscope,through latest software. 3. Embryoviewer also identifies embryos for transfer, freezing and to be discarded.

Detailed description

1. There will be two arms of the study. The Study arm in which embryos of patients will be cultured in the Embryoscope. The control arm in which the embryos of patients will be cultured under conventional conditions. 2. Embryos to be transferred will be identified by the Embryoviewer in the Study arm and the ones in the control arm will be identified by established subjective morphological criteria. 3. Embryos with definite implantation potential will be transferred in both arms. 4. Embryos not transferred will be frozen and/or discarded in both arms.

Conditions

• Embryo/Fetus Death
• Blastocyst Disintegration
• Aneuploidy
• Complication of Implant
• Chemical Pregnancy

Interventions

Type	Name	Description
DRUG	recombinant Follicle Stimulating Hormone (rFSH)	There are two arms of the study. The Study arm and the Control arm. In each arm, subjects, after randomization, will be stimulated with rFSH 225IU/day. On day 6, Cetrorelix 0.25mg/day to be added till the day of Ovitrell. Thereafter, ovum pick-up and embryo transfer to be done. Six weeks after transfer clinical pregnancy identified which will be the end-point of the study.

Timeline

• Start date: 2012-12-01
• Primary completion: 2013-03-01
• Completion: 2013-04-01
• First posted: 2013-01-04
• Last updated: 2013-01-04

Locations

1 site across 1 country: India