NCT01757379

Determination of the Bioavailability of Short Chain Fatty Acids in Healthy Humans

Evaluation of the Bioavailability and Production of Short Chain Fatty Acids in the Colon. A Stable Isotope Study in Healthy Humans.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to evaluate the bioavailability of acetate, propionate and butyrate in healthy humans using a stable isotope technology. In addition the level of acetate, propionate and butyrate production from inulin will be determined using the principle of isotope dilution.

Conditions

• Short Chain Fatty Acids Bioavailability

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	13C-labeled Acetate	400 mg of sodium acetate 1-13C (2 colon delivery capsules with 200 mg)
DIETARY_SUPPLEMENT	13C-labeled propionate	340 mg of sodium propionate 1-13C (2 colon delivery capsules with 170 mg)
DIETARY_SUPPLEMENT	13C-labeled butyrate	990 mg sodium butyrate 1-13C (2 colon delivery capsules with 495 mg)
DIETARY_SUPPLEMENT	Inulin	15 g of inulin dissolved in 200 ml of water

Timeline

• Start date: 2011-04-01
• Primary completion: 2012-04-01
• First posted: 2012-12-28
• Last updated: 2015-01-14

Locations

1 site across 1 country: Belgium