NCT01750645

Management of the Idiopathic Overactive Bladder With Botulinum Toxin: Systematic Review

Management of the Idiopathic Overactive Bladder With Intradetrusor Injection of Type-A Botulinum Toxin: Systematic Review of the Literature

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: —
• Sponsor: Clínica Infantil Colsubsidio · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Overactive bladder is defined as a syndrome composed of urgency, increased urinary frequency, and sometimes urinary incontinence; its etiology may be characterized as neurogenic or non-neurogenic (i.e., idiopathic). This illness has a great impact in quality of life and one of the available treatments is the injection of Botulinum Toxin. This study aims to review the efficacy and safety of type-A Botulinum Toxin in the management of Idiopathic Overactive Bladder. A systematic search was performed in MEDLINE, EMBASE, CENTRAL and LILACS, and the controlled randomized clinical trials were chosen to review with the CONSORT criteria by independent reviewers. Outcomes analyzed were the efficacy of the intervention for relieving the symptoms (urgency, frequency and urgency incontinence), adverse events to treatment, change in quality of life and urodynamic measures.

Conditions

• Urinary Bladder, Overactive

Interventions

Type	Name	Description
DRUG	Intradetrusor Injection of Type-A Botulinum Toxin
OTHER	Other interventions analyzed according to protocol	* Placebo * Different dosage of Type-A Botulinum Toxin injected * Anticholinergic drugs

Timeline

• Start date: 2012-07-01
• Primary completion: 2012-10-01
• Completion: 2013-01-01
• First posted: 2012-12-17
• Last updated: 2012-12-17

Locations

1 site across 1 country: Colombia