NCT01748994

Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The body shape of obese women varies between having the majority of fat either above the waist ("apple" shape) or below the waist ("pear" shape). The study will investigate what restricts: apple"-shaped women from being "pear"-shaped at the cellular level. Since "pear" shaped women tend to have better health, this study will open the door to future research in regulating body shape and thus improving health.

Detailed description

Adipose tissue expandability and the distribution of stored fat in the body are stronger predictors of health risk. A better understanding of the factors that determine regional fat mass growth may lead to developing new strategies for prevention or treatment of metabolic complications of obesity. The objective of this proposal is to study the responsiveness of different fat depots to adipogenic stimulation in upper-body and lower-body obese women.

Conditions

• Obesity
• Metabolic Syndrome

Interventions

Type	Name	Description
DRUG	Pioglitazone	30mg per day for four months
DRUG	Placebo

Timeline

• Start date: 2011-02-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2012-12-13
• Last updated: 2021-04-30
• Results posted: 2021-04-30

Locations

2 sites across 1 country: United States