NCT01739413

Effect of Anesthesia on Insulin Secretion in Patients With Preoperative Decreased Insulin Sensitivity

Effect of Epidural Anesthesia and Analgesia on Insulin Secretion in Patients With Preoperative Decreased Insulin Sensitivity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Gabriele Baldini, MD, MSc, Assistant Professor · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Epidural anesthesia has been found to manipulate the hyperglycemic response to surgery. It is unclear, however, whether the preoperative metabolic status of the surgical patient plays a role in the degree of this hyperglycemic response. For instance, the presence of low insulin sensitivity before surgery could predispose the individual to an altered metabolic response after surgery. In this case, it would be appropriate to identify adequate interventions that attenuate the response to surgical stress and facilitate the recovery process. The aims of this research projects are the following: 1. To determine the extent in which epidural local anesthetics, initiated before surgery and continued after surgery, improves insulin secretion in patients with preoperative low insulin sensitivity. 2. To understand which measures of postoperative recovery are sensitive to the restoration of insulin secretion in this particular group of patients

Conditions

• Colorectal Surgery

Interventions

Type	Name	Description
PROCEDURE	Anesthesia	Patients will be randomized to receive either epidural or general anesthesia for pain management throughout their surgery.

Timeline

• Start date: 2012-11-01
• Primary completion: 2015-10-01
• Completion: 2015-11-01
• First posted: 2012-12-03
• Last updated: 2017-10-10

Locations

1 site across 1 country: Canada