NCT01737320

Duration of Antibiotics for the Treatment of Gram-negative Bacilli Bacteremia

Duration of Antibiotics for the Treatment of Gram-negative Bacilli Bacteremia - a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 604 (actual)
• Sponsor: Rabin Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators plan an open label randomized controlled trial to compare short-course antibiotic therapy (\<=7 days) versus longer treatment (\>7 days). The investigators will include hospitalized patients with gram-negative bacteremia. The investigators primary objective is to investigate the safety and efficacy of short-course antibiotics.

Conditions

• Gram Negative Bacteremia

Interventions

Type	Name	Description
DRUG	short-course antibiotic treatment	On day 7 of appropriate intravenous or oral antibiotic treatment for the bacteremic episode (day 1 is the first day of appropriate antibiotic therapy), patients will be randomized to: 1. Intervention group - antibiotic treatment stopped on day 7 2. Control group - antibiotic treatment continued for 14 days according to accepted hospital local guidelines.
DRUG	accepted prolonged antibiotic treatment

Timeline

• Start date: 2013-01-01
• Primary completion: 2018-03-01
• Completion: 2018-03-04
• First posted: 2012-11-29
• Last updated: 2019-04-09

Locations

3 sites across 2 countries: Israel, Italy