NCT01736020

Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy

Developing Anesthesia as PTSD Therapy

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 293 (actual)
• Sponsor: Southern California Institute for Research and Education · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This preclinical phase 1 development study in healthy volunteers seeks to identify if low doses of commonly used non-triggering anesthetic agents might have clinical utility for modulating emotional memory processing and to understand the nature of the brain mechanisms of drug action. Optimally, a drug, dose and brain mechanism of action will be identified that will form the foundation for future use in clinical studies of patients with PTSD.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	A low dose of dexmedetomidine is used during scanning after dose piloting outside the scanner for memory effects and tolerability.
DRUG	Propofol	A low dose of propofol is used during scanning after dose piloting outside the scanner for memory effects and tolerability.
DRUG	Ketamine	A low dose of ketamine is used during scanning after dose piloting outside the scanner for memory effects and tolerability.
DRUG	Nitrous Oxide	A low dose of nitrous oxide is used during scanning after dose piloting outside the scanner for memory effects and tolerability.
DRUG	Placebo	Placebo

Timeline

• Start date: 2009-09-01
• Primary completion: 2017-04-01
• Completion: 2017-04-01
• First posted: 2012-11-29
• Last updated: 2016-10-13

Locations

1 site across 1 country: United States