NCT01734863

Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients

Post-operative Radiotherapy Randomization in Poor Responders Ewing's Sarcoma Patients

• Status: Withdrawn
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Children's Cancer Hospital Egypt 57357 · Academic / Other
• Sex: All
• Age: 1 Year – 18 Years
• Healthy volunteers: Not accepted

Summary

Local recurrence after surgical resection is a complex phenomenon. An important predictive factor is the response to chemotherapy. Central site of disease may be a second independent predictive factor (Lin et al. 2007). Patients with more than 10% viable tumour cells at surgery following neo-adjuvant chemotherapy had a less favourable outcome with an Event-free Survival \[EFS\] of 47% after 10 years. Patients with good histological response (\< 10% viable tumour cells) after chemotherapy alone had a prognosis of about 70% after 10 years. However, further studies are necessary to determine the merit of adjuvant radiation for high-risk patients (poor responders). Taking into consideration that the toxicity and morbidity of combined surgery and radiation is greater than either alone and must be closely monitored.

Conditions

• Ewing's Sarcoma

Interventions

Type	Name	Description
RADIATION	External Beam Radiotherapy

Timeline

• Start date: 2012-09-01
• Primary completion: 2022-09-01
• Completion: 2022-12-01
• First posted: 2012-11-28
• Last updated: 2016-01-12

Locations

1 site across 1 country: Egypt