NCT01730742

Sleep Deprivation's Regulation of Immune System Function and Behavior

The Role of Sleep Deprivation in the Regulation of Immune System, Neuroendocrine Responses, and Behavioral Measures.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Uppsala University · Academic / Other
• Sex: Male
• Age: —
• Healthy volunteers: Accepted

Summary

The study proposes to investigate whether sleep deprivation will affect a variety of measures, including hormones, immune system functioning, and behaviors related to food intake and hunger. It is predicted that sleep deprivation will affect circulating neutrophil activity, and do so via affects on DNA methylation. It is also predicted that sleep deprivation will up-regulate ghrelin, and down-regulate circulating oxytocin. Finally, it is predicted that sleep deprivation will increase participants' tendencies to pick larger portions of food, and also increase their tendency to purchase foods that are more caloric in a mock supermarket scenario.

Conditions

• Sleep Deprivation
• Sleep

Interventions

Type	Name	Description
BEHAVIORAL	Neuroeconomics task	After a night of wakefulness, participants performed the neuroeconomics task (shopping food items in a mock supermarket scenario).
BEHAVIORAL	Portion Size Task	Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume
PROCEDURE	Blood sample	After a night of wakefulness, a blood sample was taken to assess the level and efficacy of circulating neutrophils, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as oxytocin and ghrelin

Timeline

• Start date: 2012-02-01
• Primary completion: 2013-03-01
• Completion: 2013-03-01
• First posted: 2012-11-21
• Last updated: 2012-11-21

Locations

1 site across 1 country: Sweden